THYMOSIN BETA-10 LEVELS IN DEVELOPING HUMAN BRAIN AND ITS REGULATION BY RETINOIC ACID IN THE HTB-10 NEUROBLASTOMA

被引:42
作者
HALL, AK
HEMPSTEAD, J
MORGAN, JI
机构
[1] ROCHE INST MOLEC BIOL,RES CTR,DEPT NEUROSCI,NUTLEY,NJ 07110
[2] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT SURG,UROL RES LAB,NEWARK,NJ 07103
来源
MOLECULAR BRAIN RESEARCH | 1990年 / 8卷 / 02期
关键词
Developmental regulation; Differentiation; Human thymosin β10; Neuroblastoma; Retinoic acid;
D O I
10.1016/0169-328X(90)90057-K
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Human fetal brain expresses high levels of a polypeptide identified by protein biochemistry and molecular cloning as thymosin β10. Within the first 18 months after birth, the thymosin β10 content of human brain falls to undetectable levels. In order to establish the molecular basis of this process we screened a number of human tumor cell lines derived from the nervous system for the presence of thymosin β10. All of the cell line expressed authentic thymosin β10. However, in the HTB-10 neuroblastoma, retinoic acid caused a reduction in the level of thymosin β10. This effect of the retinoid was conditional upon its continual presence in the tissue culture medium and was not evident in the other cell lines examined. These results suggest that the thymosin β10 gene may be a target for retinoids in the developing nervous system. © 1990.
引用
收藏
页码:129 / 135
页数:7
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