SYNTHETIC PEPTIDES COMPRISING SEQUENCES OF THE HUMAN IMMUNOGLOBULIN-E HEAVY-CHAIN CAPABLE OF RELEASING HISTAMINE

被引：38

作者：

STANWORTH, DR ^{[1
]}

KINGS, M ^{[1
]}

ROY, PD ^{[1
]}

MORAN, JM ^{[1
]}

MORAN, DM ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,DIV RES,BETCHWORTH,SURREY,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1979年 / 180卷 / 03期

关键词：

D O I：

10.1042/bj1800665

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of previous studies on ther structure activity relationship of model polypeptide histamine liberators, a site within the Fc region of immunoglobulin E antibody molecules has been proposed as that responsible for the direct triggering of target mast cells after antigen challenge. Peptides comprising this region of the ε-chain have now been synthesized and shown to induce histamine release from normal rat peritoneal mast cells in a selective manner essentially similar to that mediated by anaphylactic antibody-antigen interaction.

引用

页码：665 / 668

页数：4

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