INDUCED MUTAGENESIS IN DAM[-]MUTANTS OF ESCHERICHIA-COLI - ROLE FOR 6-METHYLADENINE RESIDUES IN MUTATION AVOIDANCE

被引：179

作者：

GLICKMAN, B ^{[1
]}

VANDENELSEN, P ^{[1
]}

RADMAN, M ^{[1
]}

机构：

[1] UNIV BRUXELLES, DEPT BIOL MOLEC, B-1640 RHODE ST GENESE, BELGIUM

来源：

MOLECULAR AND GENERAL GENETICS | 1978年 / 163卷 / 03期

关键词：

D O I：

10.1007/BF00271960

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

E. coli strains carrying the dam-3 and dam-4 mutations resulting in reduced levels of 6-methyladenine in the DNA have been found to be more sensitive to base analogue mutagenesis than dam+ strains. Mutagenesis by EMS was also found to be enhanced in dam- strains. Dam- mutants however were not found to be hypermutable by UV light. It is concluded that the dam- strains are deficient in the correct repair of mispairing lesions. The data are consistent with the hypothesis that 6-methyladenine residues in the DNA are involved in strand discrimination during mismatch correction. © 1978 Springer-Verlag.

引用

页码：307 / 312

页数：6

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