Inflammatory Bowel Disease

被引：40

作者：

Shapiro, Jason M. ^{[1
]}

Subedi, Shova ^{[1
]}

LeLeiko, Neal S. ^{[1
]}

机构：

[1] Brown Univ, Rhode Isl Hosp, Dept Pediat,Hasbro Childrens Hosp, Div Pediat Gastroenterol Nutr & Liver Dis,Warren, Providence, RI 02903 USA

来源：

PEDIATRICS IN REVIEW | 2016年 / 37卷 / 08期

关键词：

D O I：

10.1542/pir.2015-0110

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

• On the basis of level A research, the pathogenesis of inflammatory bowel disease (IBD) is attributed to a combination of genetic and environmental factors. (1) • On the basis of level A research, various putative environmental exposures attributed to increased IBD susceptibility result in alterations in the microbiome, which is referred to as dysbiosis. (2) • On the basis of level A research, the worldwide incidence and prevalence of IBD is increasing. (3) • On the basis of level A research, biologic agents such as infliximab and adalimumab are effective therapies for pediatric patients with moderate-to-severe disease. (4)(5)(6) • On the basis of level A research, a multidisciplinary team approach that takes into account numerous biopsychosocial variables and that addresses issues related to medication adherence is important for successful management of IBD. (7). Copyright © 2016 by the American Academy of Pediatrics. All rights reserved.

引用

页码：337 / 347

页数：11

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