A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review

被引：11
|
作者：
Lee, Hae-Lim [1 ]
Cho, Sung-Yeon [1 ]
Lee, Dong-Gun [1 ,2 ]
Ko, Yumi [1 ]
Hyun, Ji In [1 ]
Kim, Bo Kyoung [1 ]
Seo, Jae Hyun [1 ]
Lee, Jung Woo [1 ]
Lee, Seok [1 ,2 ]
机构：
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Cathol Blood & Marrow Transplantat Ctr, Seoul, South Korea
来源：
INFECTION AND CHEMOTHERAPY | 2014年 / 46卷 / 03期
关键词：
Gas Gangrene; Clostridium perfringens; Neutropenia; Stem Cell Transplantation;
D O I：
10.3947/ic.2014.46.3.199
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.
引用
收藏
页码：199 / 203
页数：5
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