REGULATION OF GROWTH IN CHRONIC MYELOID-LEUKEMIA

被引：12
|
作者：
GORDON, MY
机构：
[1] Leukemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB
来源：
LEUKEMIA & LYMPHOMA | 1993年 / 11卷
关键词：
CHRONIC MYELOID LEUKEMIA; STEM CELLS; SELF-RENEWAL; DIFFERENTIATION;
D O I：
10.3109/10428199309064266
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chronic myeloid leukemia (CML) is a malignant haemopoietic stem cell disorder which results in excessive production of cells of the myeloid series. It is associated with a consistent molecular abnormality, the BCR/ABL fusion gene. The product of BCR/ABL is a p210 protein tyrosine kinase but it is not known how this dictates the biological features of the disease. This review considers several key processes that can be suggested as candidate targets for the action of p210.
引用
收藏
页码：75 / 79
页数：5
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