GDNF IS AN AGE-SPECIFIC SURVIVAL FACTOR FOR SENSORY AND AUTONOMIC NEURONS

被引：381

作者：

BUJBELLO, A ^{[1
]}

BUCHMAN, VL ^{[1
]}

HORTON, A ^{[1
]}

ROSENTHAL, A ^{[1
]}

DAVIES, AM ^{[1
]}

机构：

[1] GENENTECH INC,DEPT NEUROSCI,S SAN FRANCISCO,CA 94080

来源：

NEURON | 1995年 / 15卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0896-6273(95)90173-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of two populations of CNS neurons: motoneurons and midbrain dopaminergic neurons. To see whether GDNF promotes the survival of PNS neurons, we studied embryonic chicken autonomic and sensory neurons in culture. We show that GDNF promotes the survival of sympathetic, parasympathetic, proprioceptive, enteroceptive, and small and large cutaneous sensory neurons. Whereas sympathetic, parasympathetic, and proprioceptive neurons become less responsive to GDNF with age, enteroceptive and cutaneous sensory neurons become more responsive. GDNF mRNA is expressed in the tissues innervated by these neurons, and developmental changes in its expression in several tissues mirror the changing responses of the innervating neurons to GDNF. These results show that GDNF promotes the survival of multiple PNS and CNS neurons and suggest that GDNF may be important for regulating the survival of various populations of neurons at different stages of their development.

引用

页码：821 / 828

页数：8

共 37 条

[1] ECTOPIC-TRKA EXPRESSION MEDIATES A NGF SURVIVAL RESPONSE IN NGF-INDEPENDENT SENSORY NEURONS BUT NOT IN PARASYMPATHETIC NEURONS [J].