NM23 NUCLEOSIDE DIPHOSPHATE KINASE - TOWARD A STRUCTURAL AND BIOCHEMICAL UNDERSTANDING OF ITS BIOLOGICAL FUNCTIONS

被引：205

作者：

DELAROSA, A ^{[1
]}

WILLIAMS, RL ^{[1
]}

STEEG, PS ^{[1
]}

机构：

[1] MRC CTR,CTR PROT ENGN,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOESSAYS | 1995年 / 17卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/bies.950170111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nm23 gene, a putative metastasis suppressor gene, was originally identified by its reduced expression in highly metastatic K-1735 murine melanoma cell lines, as compared to related, low metastatic melanoma cell lines, Transfection of nm23 cDNA has been reported to suppress malignant progression in Drosophila and mammalian cells. Highly conserved homologues of nm23 have been found in organisms ranging from the prokaryote Myxococcus xanthus to Drosophila, where the gene is involved in normal development and differentiation. The product of the nm23 gene exhibits a nucleoside diphosphate kinase activity, yet the nucleoside diphosphate kinase activity of Nm23 does not correlate with its apparent biological functions. We review recent cellular, genetic, biochemical and Xray crystallographic data to formulate and evaluate hypotheses concerning the molecular mechanism of nm23 action.

引用

页码：53 / 62

页数：10

共 57 条

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