NEUROTROPHIN-4 SELECTIVELY PROMOTES SURVIVAL OF STRIATAL NEURONS IN ORGANOTYPIC SLICE CULTURE

被引：46
作者：
ARDELT, AA
FLARIS, NA
ROTH, KA
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL,ST LOUIS,MO 63110
来源：
BRAIN RESEARCH | 1994年 / 647卷 / 02期
关键词：
NEUROTROPHIC EFFECT; BASAL GANGLIA; HUNTINGTONS DISEASE; EXPLANT CULTURE;
D O I：
10.1016/0006-8993(94)91333-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The neurotrophins (NGF, BDNF, NT-3, and NT-4) provide trophic support to subpopulations of neurons in the central and peripheral nervous systems. We examined organotypic slices of neonatal mouse striatum maintained in medium supplemented with neurotrophins or with CNTF to determine which of these factors influence the survivability of striatal neurons. Neuron counts at the end of the culture period revealed that NT-4 was the only factor that had a significant effect on neuronal survival, suggesting that NT-4 is a trophic factor for striatal neurons in organotypic slices.
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页码：340 / 344
页数：5
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