ASSIGNMENT OF N-15-NMR RESONANCES OF VITAMIN-B12 ANALOGS BY 2D-[N-15,H-1] LONG-RANGE CORRELATION - FULLY [N-15]-LABELED CO-BETA-CYANO-5-HYDROXYBENZIMIDAZOYLCOBAMIDE (FACTOR-III) AND DERIVATIVES

被引：10
|
作者：
HOLLENSTEIN, R
STUPPERICH, E
机构：
[1] UNIV ULM,ALBERT EINSTEIN ALLEE 11,W-7900 ULM,GERMANY
[2] UNIV ZURICH,INST ORGAN CHEM,CH-8057 ZURICH,SWITZERLAND
来源：
HELVETICA CHIMICA ACTA | 1993年 / 76卷 / 03期
关键词：
D O I：
10.1002/hlca.19930760312
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The N-15-NMR spectra of vitamin B-12 analogues obtained in fully N-15-labelled form have been measured by direct and inverse (N-15,H-1) correlated spectroscopy. All resonances, except those of the NH2 groups, have been assigned to individual N-atoms. The influences on 6 (N) are analyzed and discussed which are caused by changing the beta-face ligand from CN to H2O or CH3 and by switching the alpha-face ligand from the base-on to the base-off state. An implication of the correct resonance assignment of biosynthetic pathways is demonstrated.
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页码：1258 / 1265
页数：8
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