PREDICTION OF SOLUBILITY OF SULFONAMIDES IN WATER AND ORGANIC-SOLVENTS BASED ON THE EXTENDED REGULAR SOLUTION THEORY

被引：28
|
作者：
REGOSZ, A
PELPLINSKA, T
KOWALSKI, P
THIEL, Z
机构：
[1] Faculty of Pharmacy, Medical Academy of Gdańsk, 80-416 Gdańsk
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 88卷 / 1-3期
关键词：
SULFONAMIDE; SOLUBILITY PREDICTION; DIELECTRIC CONSTANT; SOLVATOCHROMIC POLARITY PARAMETER; HILDEBRAND APPROACH;
D O I：
10.1016/0378-5173(92)90344-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A method for prediction of the solubility of sulfonamides in water and in some organic solvents based on the modified Hildebrand-Scatchard equation for regular solutions is described. Introduction into the equation of the dielectric constant or solvatochromic polarity parameter of the solvent allows the applicability of regular solution theory to be extended to polar systems which are widely employed in pharmaceutical practice. The predicted solubilities of 14 sulfonamides in water at various temperatures and of eight sulfonamides in organic solvents of different polarity were compared with those determined experimentally.
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页码：437 / 442
页数：6
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