Effect of crystallization of caffeic acid enhanced stability and dual biological efficacy

被引：4

作者：

Khan, Md Shamsuddin Sultan ^{[1
]}

Iqbal, Muhammad Adnan ^{[2
]}

Majid, Amin Malik Shah Abdul ^{[1
]}

机构：

[1] Univ Sci Malaysia, Sch Pharmaceut Sci, George Town, Malaysia

[2] Univ Sci Malaysia, Sch Chem Sci, George Town, Malaysia

来源：

COGENT BIOLOGY | 2016年 / 2卷 / 01期

关键词：

caffeic acid; rosmarinic acid; neuroprotective activity; cytotoxicity; crystallography; cancer; Alzheimer's diseases;

D O I：

10.1080/23312025.2016.1243460

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Caffeic acid (CA) is a well-known natural compound used for both health supplement and metabolic diseases. In the present study, single, easy, and quick isolation procedure of caffeic acid was described from rosmarinic acid. A quick crystal formation also was described for highly hygroscopic CA which was spontaneous and stable with lower hygroscopic nature. In addition, the produced crystal CA was highly stable and showed neuroprotective activity with <6 mu g/ml in R28 cell line and cytotoxic activity with >100 mu g/ml in U87 MG which revealed its dual biological effect for the treatment of Alzheimer's disease and cancer, respectively.

引用

页数：8

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