THE USE OF NASAL MUPIROCIN OINTMENT TO PREVENT STAPHYLOCOCCUS-AUREUS BACTEREMIAS IN HEMODIALYSIS-PATIENTS - AN ANALYSIS OF COST-EFFECTIVENESS

被引:31
|
作者
BOELAERT, JR
DEBAERE, YA
GEERNAERT, MA
GODARD, CA
VANLANDUYT, HW
机构
[1] ALGEMEEN ZIEKENHUIS ST JAN,DEPT MICROBIOL,BRUGES,BELGIUM
[2] INST PASTEUR,LYSOTYPIE LAB,B-1040 BRUSSELS,BELGIUM
关键词
MUPIROCIN; STAPHYLOCOCCUS-AUREUS; HEMODIALYSIS; BACTEREMIA;
D O I
10.1016/0195-6701(91)90202-J
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Nasal carriage of Staphylococcus aureus is a risk factor for the development of infections caused by S. aureus in haemodialysis patients. This study compared the incidence of bacteraemia caused by S. aureus during 6 months of use of nasal 2% calcium mupirocin ('Nasal Bactroban') 3-times a week for nasal carriers with the incidence observed previously in the same dialysis unit without the use of mupirocin. Nasal mupirocin led to the total eradication of nasal carriage of S. aureus, a 4·26-fold reduction in the incidence of S. aureus bacteraemia, and a substantial cost saving. After a cumulative experience of nasal mupirocin in haemodialysis patients of more than 43 patient-years, the development of mupirocin resistance was not observed. © 1991.
引用
收藏
页码:41 / 46
页数:6
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