MIDTRIMESTER TERMINATION OF PREGNANCY WITH 16,16-DIMETHYL-TRANS-DELTA-2 PGE1 VAGINAL PESSARIES - A COMPARISON WITH INTRAAMNIOTIC AND EXTRAAMNIOTIC PROSTAGLANDIN-E2 ADMINISTRATION

被引：9

作者：

HILL, NCW ^{[1
]}

SELINGER, M ^{[1
]}

FERGUSON, J ^{[1
]}

MACKENZIE, IZ ^{[1
]}

机构：

[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL,OXFORD OX3 9DU,ENGLAND

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 1991年 / 35卷 / 04期

关键词：

PROSTAGLANDIN; ABORTION;

D O I：

10.1016/0020-7292(91)90668-U

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

PGE1 analogue (gemeprost) vaginal pessaries administered three hourly for three doses has been compared with a single extra- or intra-amniotic injection of PGE2 for mid-trimester termination of pregnancy in 450 women between 13 and 20 weeks gestation. The mean (SD) induction-abortion interval (IAI) in the vaginal pessary group of 19.5 (8.4) h was significantly longer than the respective intervals of 14.4 (9.3) and 16.1 (6.8) h in the patients treated extra- or intra-amniotically (P < 0.001). Seventy-three percent treated with gemeprost aborted within 24 h of initial treatment compared with 84% and 87%, respectively in the extra- and intra-amniotic groups (P < 0.05). Patients treated with gemeprost were more likely to need further prostaglandin treatment and had an increased incidence of gastrointestinal side effects. Despite these differences vaginal gemeprost pessaries provide a safe, effective, easy to administer method for midtrimester termination of pregnancy.

引用

页码：337 / 340

页数：4