Aprotinin in cardiac surgery - re-evaluation of the risks?

被引:0
作者
Vanek, T. [1 ]
Hlavicka, J. [1 ]
Budera, P. [1 ]
机构
[1] Kardiochirurg Klin 3 LF UK, Srobarova 50, Prague 10034 10, Czech Republic
来源
ANESTEZIOLOGIE A INTENZIVNI MEDICINA | 2016年 / 27卷 / 05期
关键词
cardiac surgery; fibrinolysis; fibrinolytic inhibitors; aprotinin;
D O I
暂无
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The article describes the history of introducing aprotinin into cardio-surgical clinical practice and deals with the circumstances based on the results of the BART study leading to its withdrawal from the global pharmaceutical market and with its recent re-authorization in some countries.
引用
收藏
页码:284 / 288
页数:5
相关论文
共 50 条
  • [41] Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery
    Ide, Masahiro
    Bolliger, Daniel
    Taketomi, Taro
    Tanaka, Kenichi A.
    JOURNAL OF ANESTHESIA, 2010, 24 (01) : 96 - 106
  • [42] REVERSAL OF STREPTOKINASE-INDUCED BLEEDING WITH APROTININ FOR EMERGENCY CARDIAC-SURGERY
    AKHTAR, TM
    GOODCHILD, CS
    BOYLAN, MKG
    ANAESTHESIA, 1992, 47 (03) : 226 - 228
  • [43] Aprotinin Reduces the Procalcitonin Rise Associated With Complex Cardiac Surgery and Cardiopulmonary Bypass
    Maruna, P.
    Klein, A. A.
    Kunstyr, J.
    Plocova, K. M.
    Mlejnsky, F.
    Lindner, J.
    PHYSIOLOGICAL RESEARCH, 2013, 62 (01) : 27 - 33
  • [44] Efficacy of a High-dose Aprotinin Regimen for Reducing Transfusion Requirements and Inflammatory Responses in Adult Cardiac Surgery
    Jeong, D. S.
    Kim, K-H
    Kim, C. Y.
    Kim, J. S.
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2008, 36 (05) : 1039 - 1048
  • [45] CASE 1-2008 - One institution's decreasing use of aprotinin during cardiac surgery in 2006
    Strouch, Zaneta Y.
    Chaney, Mark A.
    Augoustides, John G. T.
    Spiess, Bruce D.
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2008, 22 (01) : 139 - 146
  • [46] Measurement of endotoxin, IL-6, IL-8 and blood lactate after cardiac surgery: re-evaluation of the systemic inflammatory response induced by cardiopulmonary bypass
    K Masayuki
    T Kikuchi
    J Sunanaga
    K Kitahara
    N Okayama
    T Moriyama
    T Omae
    Y Kakihana
    Y Kanmura
    T Arimura
    Critical Care, 7 (Suppl 2):
  • [47] Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery
    Sabzi, Feridoun
    Moradi, Gholam Reza
    Dadkhah, Heidar
    Poormotaabed, Alireza
    Dabiri, Samsam
    JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2012, 17 (01): : 74 - 82
  • [48] Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery
    Masahiro Ide
    Daniel Bolliger
    Taro Taketomi
    Kenichi A. Tanaka
    Journal of Anesthesia, 2010, 24 : 96 - 106
  • [49] Benefits and Risks of Epidural Analgesia in Cardiac Surgery
    Mehta, Yatin
    Arora, Dheeraj
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2014, 28 (04) : 1057 - 1063
  • [50] Aprotinin and the risk of death and renal dysfunction in patients undergoing cardiac surgery: a meta-analysis of epidemiologic studies
    Gagne, Joshua J.
    Griesdale, Donald E. G.
    Schneeweiss, Sebastian
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2009, 18 (04) : 259 - 268