SYMPATHOADRENAL MECHANISMS UNDERLYING CARDIOVASCULAR-RESPONSES TO INTRATHECAL SUBSTANCE-P IN CONSCIOUS RATS

被引:26
作者
HASSESSIAN, H
COUTURE, R
DECHAMPLAIN, J
机构
[1] Groupe de Recherche sur le Systeme Nerveux Autonome, Department of Physiology, Faculty of Medicine University of Montreal, Montreal, QC
关键词
Cardiovascular system; Catecholamines; Neuropeptide Y; Spinal cord; Substance P;
D O I
10.1097/00005344-199005000-00008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The sympathoadrenal mechanisms underlying cardiovascular responses to intrathecal (i.th.) injection of substance P (SP), at the T-9 spinal level, were investigated in conscious rats. Release of norepinephrine (NE), and epinephrine (EPI) could be induced by 6.5, 16.25, and 32.5 nmol SP correlated with a pressor and a positive chronotropic response. Release of neuropeptide Y (NPY) was evoked also by 32.5 nmol SP, and released NPY appears to derive from the adrenal medulla. The initial pressor response in intact rats is mediated by NE from sympathetic fibers, whereas the latent pressor response, observed in sympathectomized rats, is possibly due to NPY from the adrenal medulla. Although a functional balance between the sympathetic fibers and the adrenal glands is supported by the results, it appears that only the tachycardia can be efficiently produced by the adrenals in the absence of the sympathetic fibers. This study supports a functional role for SP in regulation of the sympathoadrenal system at the spinal level. © 1990 Raven Press, Ltd., New York.
引用
收藏
页码:736 / 744
页数:9
相关论文
共 38 条
[1]   LOCALIZATION OF NEUROPEPTIDE-Y IN NERVES OF THE RAT CARDIOVASCULAR-SYSTEM AND THE EFFECT OF 6-HYDROXYDOPAMINE [J].
ALLEN, JM ;
POLAK, JM ;
RODRIGO, J ;
DARCY, K ;
BLOOM, SR .
CARDIOVASCULAR RESEARCH, 1985, 19 (09) :570-577
[2]  
AUBERT JF, 1988, J PHARMACOL EXP THER, V244, P1109
[3]   DO LOCAL VASOMOTOR EFFECTS ELICIT THE MOTOR DEFICITS INDUCED BY INTRATHECALLY APPLIED SUBSTANCE-P ANTAGONISTS IN THE RAT [J].
BARBER, A ;
WILD, A ;
WEDEL, R .
NEUROSCIENCE LETTERS, 1987, 80 (02) :219-223
[4]  
BURNSTOCK G, 1987, Journal of Cardiovascular Pharmacology, V10, pS74, DOI 10.1097/00005344-198710012-00010
[5]   FUNCTION OF THE VENTROLATERAL MEDULLA IN THE CONTROL OF THE CIRCULATION [J].
CIRIELLO, J ;
CAVERSON, MM ;
POLOSA, C .
BRAIN RESEARCH REVIEWS, 1986, 11 (04) :359-391
[6]   STUDIES ON THE CARDIOVASCULAR EFFECTS PRODUCED BY THE SPINAL ACTION OF SUBSTANCE-P IN THE RAT [J].
COUTURE, R ;
HASSESSIAN, H ;
GUPTA, A .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1988, 11 (03) :270-283
[7]   DISTRIBUTION OF LABEL AFTER INTRATHECAL ADMINISTRATION OF I-125 SUBSTANCE-P IN THE RAT [J].
CRIDLAND, RA ;
YASHPAL, K ;
ROMITA, VV ;
GAUTHIER, S ;
HENRY, JL .
PEPTIDES, 1987, 8 (02) :213-221
[8]   NEUROPEPTIDE-Y (NPY) - ENHANCEMENT OF BLOOD-PRESSURE INCREASE UPON ALPHA-ADRENOCEPTOR ACTIVATION AND DIRECT PRESSOR EFFECTS IN PITHED RATS [J].
DAHLOF, C ;
DAHLOF, P ;
LUNDBERG, JM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 109 (02) :289-292
[9]   REGULATION OF BLOOD-PRESSURE BY SYMPATHETIC-NERVE FIBERS AND ADRENAL-MEDULLA IN NORMOTENSIVE AND HYPERTENSIVE RATS [J].
DE CHAMPLAIN, J ;
VAN AMERINGEN, MR .
CIRCULATION RESEARCH, 1972, 31 (04) :617-+
[10]  
DECHAMPLAIN J, 1977, HYPERTENSION, P76