GAS CHROMATOGRAPHY OF CATECHOLAMINE METABOLITES USING ELECTRON CAPTURE DETECTION AND MASS SPECTROMETRY

被引：125
作者：
ANGGARD, E
SEDVALL, G
机构：
[1] Department of Pharmacology, Karolinska Institutet, Stockholm
来源：
ANALYTICAL CHEMISTRY | 1969年 / 41卷 / 10期
关键词：
D O I：
10.1021/ac60279a042
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Conditions were studied for the gas chromatography of normetanephrine, metanephrine, 3-methoxytyra-mine, 3-methoxy-4-hydroxyphenyl ethylene glycol, vanillylmandelic acid, and homovanillic acid with electron capture (EC) detection and mass spectrometry. Pentafluoropropionates (PFP) and heptafluorobutyrates were more stable and had higher EC-responses than the corresponding trifluoroacetates. These derivatives were also used to separate the amines on XE-60 and the deaminated metabolites on OV-17. The linear range with the63Ni EC-detector was 0,02-0.8 ng for the PFP-derivatives. Mass spectra were obtained from the perfluoroacylated, trimethylsilylated, and acetylated metabolites. © 1969, American Chemical Society. All rights reserved.
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页码：1250 / &
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