VINYL ETHER HYDROLYSIS . SPECIFIC ACID CATALYZED HYDROLYSIS OF 4-METHOXY-3-BUTEN-2-ONE

被引：18

作者：

FEDOR, LR

MCLAUGHLIN, J

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1969年 / 91卷 / 13期

关键词：

D O I：

10.1021/ja01041a027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrolysis of 4-methoxy-3-buten-2-one (1) to 3-ketobutanal in aqueous solution is specific acid catalyzed and is further characterized by k2(D20)k2(H20) = 2.08 and ∆S± = –26.0 ±1.7 eu. These results are consonant with an A2 mechanism involving rate-determining hydrolysis of the conjugate acid of 1. © 1969, American Chemical Society. All rights reserved.

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页码：3594 / +

页数：1

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