ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF TAXILLUS TOMENTOSUS PLANT ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN WISTAR RATS

被引：3
|
作者：
Venkateswarlu, Kambham [1 ]
Preethi, Jami Komala [2 ]
Chandrasekhar, K. B. [3 ]
机构：
[1] Jawaharlal Nehru Technol Univ Anantapur, JNTUA Oil Tech & Pharm Res Inst, Dept Pharmaceut, Anantapur 515001, Andhra Pradesh, India
[2] Jawaharlal Nehru Technol Univ Anantapur, JNTUA Oil Tech & Pharm Res Inst, Anantapur 515001, Andhra Pradesh, India
[3] Jawaharlal Nehru Technol Univ Anantapur, JNTUA Oil Tech & Pharm Res Inst, Dept Chem, Anantapur 515001, Andhra Pradesh, India
来源：
INDONESIAN JOURNAL OF PHARMACY | 2016年 / 27卷 / 02期
关键词：
anti-urolithiatic activity; taxillus tomentosus; ethylene glyco; ammonium chloride; cystone;
D O I：
10.14499/indonesianjpharm27iss2pp66
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study investigates the potential of antiurolithiatic activity of ethanolic extract of Taxillus tomentosus plant (EETT). Urolithiasis was induced by feeding the 0.75% of Ethylene glycol (EG) and 2% of Ammonium chloride (AC) in drinking water along with the normal feed in male wistar rats and then the anti-urolithiatic activity of EETT was evaluated. Acute toxicity study was conducted by LD50 cutoff dose of 2000mg/kg body weight (BW), indicates that the drug to be much safer and 1/10th (200mg/kg BW) and 1/5th (400mg/kg BW) of LD50 doses were selected for study. Serum and urine samples were analyzed for knowing the concentration of creatinine, calcium, urea, uric acid, oxalates and during the entire study, urolithiatic animals showed significantly high concentrations than normal animals. The EETT (200mg/kg BW and 400mg/kg BW) was showed good response to antiurolithiatic activity when compared to the standard drug cystone (CST).
引用
收藏
页码：66 / 73
页数：8
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