Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury

被引:15
作者
Chen, Lung-Che [1 ]
Hu, Li-Hong [2 ]
Yin, Mei-Chin [3 ]
机构
[1] Taipei Med Univ Hosp, Dept Otolaryngol, Taipei 110, Taiwan
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
[3] China Med Univ, Dept Nutr, 91 Hsueh Shih Rd, Taichung 404, Taiwan
来源
BIOMEDICINE-TAIWAN | 2016年 / 6卷 / 02期
关键词
Acetaminophen; Boswellic acid; CYP2E1; JNK; TLRs; NF-kappa B;
D O I
10.7603/s40681-016-0009-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Protective effects of boswellic acid (BA) against acetaminophen (APAP)-induced hepatotoxicity in Balb/cA mice were examined. BA, at 0.05 or 0.1%, was supplied for 4 weeks. Acute liver injury was induced by APAP treatment. Results showed that BA intake increased hepatic BA bioavailability. APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase(HO)-1 in liver. BA intake at both doses alleviated subsequent APAP-induced oxidative stress by retaining GSH content, decreasing ROS and GSSG formations, reserving activity and expression of GR and HO-1 in liver, and lowering hepatic cytochrome P450 2E1 activity and expression. APAP treatment enhanced hepatic levels of interleukin-6, tumor necrosis factor-alpha and monocyte chemoattractant protein-1. BA pre-intake diminished APAP-induced release of those inflammatory cytokines and chemokines. APAP upregulated hepatic protein expression of toll-like receptor (TLR)-3, TLR-4, MyD88, nuclear factor kappa B (NF-kappa B) p50, NF-kappa B p65 and JNK. BA pre-intake at both doses suppressed the expression of NF-kappa B p65 and p-JNK, and only at 0.1% down-regulated hepatic TLR-3, TLR-4 and MyD88 expression. APAP led to obvious foci of inflammatory cell infiltration in liver, determined by H&E stain. BA intake at both doses attenuated hepatic inflammatory infiltration. These findings support that boswellic acid is a potent hepatoprotective agent.
引用
收藏
页码:12 / 19
页数:8
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