CLORGYLINE EFFECT ON PINEAL MELATONIN BIOSYNTHESIS IN ROMAN HIGH-AVOIDANCE AND LOW-AVOIDANCE RATS

被引：0

作者：

REQUINTINA, PJ

DRISCOLL, P

OXENKRUG, GF

机构：

[1] BROWN UNIV,SCH MED,DEPT PSYCHIAT & HUMAN BEHAV,PROVIDENCE,RI 02912

[2] ETHZ,BEHAV BIOL LAB,ZURICH,SWITZERLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 1994年 / 41期

关键词：

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pineal melatonin and related indoles levels were higher in Roman high- than in Roman low-avoidance rats, while 5-HIAA/5-HT ratio, as an index of MAO activity was higher in low- than in high-avoidance rats. Clorgyline stimulated pineal melatonin biosynthesis in both lines of rats. However, melatonin and N-acetylserotonin levels remained higher and 5-HIAA levels remained lower in the high avoidance rats treated with low dose (0.5 mg/kg) while treatment with 1.0 mg/kg of clorgyline eliminated the differences in melatonin production between high- and low-avoidance rats.

引用

页码：145 / 148

页数：4

共 9 条

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