TRANSGENIC MOUSE MODELS OF LIPOPROTEIN METABOLISM AND ATHEROSCLEROSIS

被引：118
作者：
BRESLOW, JL
机构：
[1] Biochemical Genetics/Metabolism Lab., Rockefeller University, New York, NY 10021-6399
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 18期
关键词：
APOLIPOPROTEIN; DIET; CHOLESTEROL;
D O I：
10.1073/pnas.90.18.8314
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Lipoprotein transport genes have either been added to the germ line of mice by transgenic techniques or knocked out by homologous recombination in embryonic stem cells. The resultant over- or underexpression of these genes has resulted in new insights about how these genes function in the body and their role in lipoprotein metabolism. Either singly or in combination, these genetic modifications can be used to engineer the mouse to make it a better model for human lipoprotein disorders and atherosclerosis.
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收藏
页码：8314 / 8318
页数：5
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