Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

被引：5

作者：

Zhang, Li-Jun ^{[1
]}

Wang, Lai-Xing ^{[2
]}

Zhang, Wei-Li ^{[1
]}

Yan, Yi-Jia ^{[1
]}

Chen, Zhi-Long ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem & Biol, Dept Pharmaceut Sci & Technol, Shanghai 201620, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Shanghai 200433, Peoples R China

来源：

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2015年 / 8卷 / 01期

关键词：

TPMC; chlorin; tumor; photosensitizer; photodynamic therapy; PHOTOSENSITIZERS; FLUORESCENCE; DEATH;

D O I：

10.1142/S1793545815400039

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm(2), 1.2 to 3.6 J/cm(2)) and destroy Eca-109 tumor in nude mice (50mW/cm(2), 90 J/cm(2)). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.

引用

页数：11

共 35 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] Synthesis and biological evaluation of new chlorin derivatives as potential photosensitizers for photodynamic therapy [J].

Asano, Ryuji ;

Nagami, Amon ;

Fukumoto, Yuki ;

Yazama, Futoshi ;

Ito, Hideyuki ;

Sakata, Isao ;

Tai, Akihiro .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (08) :2298-2304

[3] Comparative in vitro study on the characteristics of different photosensitizers employed in PDT [J].

Berlanda, Juergen ;

Kiesslich, Tobias ;

Engelhardt, Victoria ;

Krammer, Barbara ;

Plaetzer, Kristjan .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2010, 100 (03) :173-180

[4] Molecular effectors of multiple cell death pathways initiated by photodynamic therapy [J].

Buytaert, Esther ;

Dewaele, Michael ;

Agostinis, Patrizia .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2007, 1776 (01) :86-107

[5] Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].

Celli, Jonathan P. ;

Spring, Bryan Q. ;

Rizvi, Imran ;

Evans, Conor L. ;

Samkoe, Kimberley S. ;

Verma, Sarika ;

Pogue, Brian W. ;

Hasan, Tayyaba .

CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838

[6] Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer [J].

Cheng, Yu ;

Samia, Anna C. ;

Meyers, Joseph D. ;

Panagopoulos, Irene ;

Fei, Baowei ;

Burda, Clemens .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) :10643-10647

[7] In-vivo optical detection of cancer using chlorin e6 - Polyvinylpyrrolidone induced fluorescence imaging and spectroscopy [J].

Chin W.W.L. ;

Thong P.S.P. ;

Bhuvaneswari R. ;

Soo K.C. ;

Heng P.W.S. ;

Olivo M. .

BMC Medical Imaging, 9 (1)

[8] Tissue Uptake Study and Photodynamic Therapy of Melanoma-Bearing Mice with a Nontoxic, Effective Chlorin [J].

Dabrowski, Janusz M. ;

Krzykawska, Martyna ;

Arnaut, Luis G. ;

Pereira, Mariette M. ;

Monteiro, Carlos J. P. ;

Simoes, Sergio ;

Urbanska, Krystyna ;

Stochel, Grazyna .

CHEMMEDCHEM, 2011, 6 (09) :1715-1726

[9]

Dewaele M, 2010, METHODS MOL BIOL, V635, P7, DOI 10.1007/978-1-60761-697-9_2

[10] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

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