EFFECTS OF SELEGILINE DOSING ON MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE

被引：21

作者：

HUBBLE, JP ^{[1
]}

KOLLER, WC ^{[1
]}

WATERS, C ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90089

来源：

CLINICAL NEUROPHARMACOLOGY | 1993年 / 16卷 / 01期

关键词：

SELEGILINE; DEPRENYL; PARKINSON DISEASE; MOTOR FLUCTUATION;

D O I：

10.1097/00002826-199302000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To examine selegiline's dosing effects, we studied 16 Parkinson disease patients with motor fluctuations in a double-blind, crossover trial of selegiline at 0, 5, and 10 mg daily. Patients' motor diaries, disability scores, and walking speed were marginally improved, with no advantage of 10 mg over 5 mg found. We conclude that in patients with motor fluctuations, selegiline provides modest symptomatic effects, with daily dosing of 5 mg being indistinguishable from 10 mg.

引用

页码：83 / 87

页数：5

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