EFFECTS OF SELEGILINE DOSING ON MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE

被引：21
|
作者：
HUBBLE, JP [1 ]
KOLLER, WC [1 ]
WATERS, C [1 ]
机构：
[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90089
来源：
CLINICAL NEUROPHARMACOLOGY | 1993年 / 16卷 / 01期
关键词：
SELEGILINE; DEPRENYL; PARKINSON DISEASE; MOTOR FLUCTUATION;
D O I：
10.1097/00002826-199302000-00010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To examine selegiline's dosing effects, we studied 16 Parkinson disease patients with motor fluctuations in a double-blind, crossover trial of selegiline at 0, 5, and 10 mg daily. Patients' motor diaries, disability scores, and walking speed were marginally improved, with no advantage of 10 mg over 5 mg found. We conclude that in patients with motor fluctuations, selegiline provides modest symptomatic effects, with daily dosing of 5 mg being indistinguishable from 10 mg.
引用
收藏
页码：83 / 87
页数：5
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