RAT-LIVER LYSOSOME MEMBRANES ARE ENRICHED IN ALPHA-TOCOPHEROL

被引：16
|
作者：
RUPAR, CA
ALBO, S
WHITEHALL, JD
机构：
[1] UNIV WESTERN ONTARIO,DEPT PEDIAT,LONDON N6A 5C1,ONTARIO,CANADA
[2] CHILDRENS PSYCHIAT RES INST,LONDON N6H 3W7,ONTARIO,CANADA
来源：
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1992年 / 70卷 / 06期
关键词：
ALPHA-TOCOPHEROL; LYSOSOMES; MITOCHONDRIA; MEMBRANE;
D O I：
10.1139/o92-075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The subcellular distribution of alpha-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in alpha-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of alpha-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states.
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页码：486 / 488
页数：3
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