Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

被引：22
作者：
Abheiden, Carolien N. H. [1 ]
van Doornik, Rebecca [1 ]
Aukes, Annet M. [1 ]
van der Flier, Wiesje M. [2 ,3 ]
Scheltens, Philip [2 ]
de Groot, Christianne J. M. [1 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Obstet & Gynecol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2015年 / 5卷 / 03期
关键词：
Alzheimer's disease; Magnetic resonance imaging; Preeclampsia; Pregnancy-induced hypertension; Early-onset dementia;
D O I：
10.1159/000439043
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD). Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD. Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed. Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD. Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：375 / 385
页数：11
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