PHARMACOKINETICS OF PEMOLINE IN PLASMA, SALIVA AND URINE FOLLOWING ORAL-ADMINISTRATION

被引：23

作者：

VERMEULEN, NPE ^{[1
]}

TEUNISSEN, MWE ^{[1
]}

BREIMER, DD ^{[1
]}

机构：

[1] UNIV LEIDEN,SUBFAC PHARM,DEPT PHARMACEUT ANAL,NL-2300 RA LEIDEN,NETHERLANDS

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 8卷 / 05期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb01026.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half‐live of 11.0 +/‐ 1.2 h (n=4). Peak levels were reached at 2.7 +/‐ 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/‐ 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/‐ 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half‐lives were slightly shorter than the corresponding plasma half‐lives. 1979 The British Pharmacological Society

引用

页码：459 / 463

页数：5