Evaluating the Fat Distribution in Idiopathic intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning

被引：47

作者：

Hornby, Catherine ^{[1
]}

Botfield, Hannah ^{[1
]}

O'Reilly, Michael W. ^{[1
,2
]}

Westgate, Connar ^{[1
]}

Mitchell, James ^{[1
,2
,3
]}

Mollan, Susan P. ^{[1
,4
]}

Manolopoulos, Konstantinos ^{[1
,2
]}

Tomlinson, Jeremy ^{[2
,5
]}

Sinclair, Alexandra ^{[1
,2
,3
]}

机构：

[1] Univ Birmingham, Coll Med & Dent Sci, Inst Metab & Syst Res, Birmingham B15 2TT, W Midlands, England

[2] Birmingham Hlth Partners, Ctr Endocrinol Diabet & Metab, Birmingham, W Midlands, England

[3] Univ Hosp Birmingham NHS Fdn Trust, Dept Neurol, Birmingham, W Midlands, England

[4] Univ Hosp Birmingham NHS Trust, Queen Elizabeth Hosp Birmingham, Ophthalmol Dept, Birmingham Neuroophthalmol Unit, Birmingham, W Midlands, England

[5] Univ Oxford, OCDEM, Oxford, England

来源：

NEURO-OPHTHALMOLOGY | 2018年 / 42卷 / 02期

基金：

英国医学研究理事会;

关键词：

DEXA; idiopathic intracranial hypertension; obesity;

D O I：

10.1080/01658107.2017.1334218

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients (n = 24) had a similar fat distribution to body mass index (BMI)- and gender-matched obese controls (n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (-4.40 +/- 1.6%; p = 0.008) compared with the limbs (+0.79 +/- 6.5%; p = 0.71). These results indicate that, contrary to previous studies using waist-hip ratios, IIH adiposity is centripetal, similar to simple obesity. Future studies should establish the risk of the metabolic syndrome and the role of adipose tissue depot-specific function in IIH.

引用

页码：99 / 104

页数：6

共 26 条

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