Assessment of Antioxidant and Anti - Lipid Peroxidation Capability of Guduchi (Tinospora cordifolia)

被引:0
作者
Sudhakar, Sruthi [1 ]
Joshi, Lokesh Kumar [2 ]
Sehgal, Amit [1 ]
机构
[1] Lovely Profess Univ, Sch Biotechnol & Biosci, Phagwara 144806, Punjab, India
[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144806, Punjab, India
来源
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2015年 / 6卷 / 05期
关键词
Guduchi; Antioxidant; Anti lipid peroxidation; Oxidative stress;
D O I
暂无
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Many oxidative stress related diseases like cancer, diabetes, neurodegenerative disorders and cardiovascular diseases are occurring as a result of accumulation of free radicals in the body. Tinospora cordifolia (Guduchi) is a medicinal herb used in the Indian system of medicine due to its health benefits. In the present study, the antioxidant activity of Guduchi extract was investigated using various in vitro methods such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), nitric oxide (NO), hydroxyl (OH), hydrogen peroxide radical scavenging and anti-lipid peroxidation assays. The results indicated that IC50 values of Guduchi extract were 0.997mg/ml in DPPH, 0.72mg/ml in ABTS, 10.7mg/ml in NO, 3.1mg/ml in H2O2, 0.86mg/ml in hydroxyl radical scavenging and 109mg/ml in antilipid peroxidation. The results revealed that Guduchi extract has promising antioxidant activity and could serve as potential source of natural antioxidants.
引用
收藏
页码:458 / 463
页数:6
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