Reviewing the controversy surrounding pre-treatment with P2Y(12) inhibitors in acute coronary syndrome patients

被引：11

作者：

Capodanno, Davide ^{[1
]}

Angiolillo, Dominick J. ^{[2
]}

机构：

[1] Univ Catania, Ferrarotto Hosp, Catania, Italy

[2] Univ Florida, Coll Med Jacksonville, 655 West 8th St, Jacksonville, FL 32209 USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2016年 / 14卷 / 07期

关键词：

Pretreatment; loading dose; prasugrel; ticagrelor; preloading;

D O I：

10.1586/14779072.2016.1164035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pretreatment with oral P2Y(12) inhibitors occurs each time clopidogrel, prasugrel, ticagrelor are given to patients with suspected coronary artery disease before definition of the coronary anatomy. In acute coronary syndromes, the practice of administering oral P2Y(12) inhibitors upstream has been the object of significant controversy in recent years, following the publication of two trials of pretreatment in non-ST-segment elevation acute coronary syndromes and ST-segment elevation myocardial infarction, respectively. The introduction in the market of cangrelor - the first intravenous P2Y(12) inhibitor - represents a new opportunity but also a new challenge for clinicians. This article reviews current recommendations and supporting evidence surrounding pretreatment with oral and intravenous P2Y(12) inhibitors in patients with acute coronary syndromes.

引用

页码：811 / 820

页数：10

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