BETA-ADRENOCEPTORS AND REGENERATING CORNEAL EPITHELIUM

被引：17

作者：

LIU, GS ^{[1
]}

TROPE, GE ^{[1
]}

BASU, PK ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT OPHTHALMOL,1 SPADINA CRESCENT,TORONTO M55 2K6,ONTARIO,CANADA

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1089/jop.1990.6.101

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Beta blockers inhibit corneal re-epithelialization. This may be due to beta-2 receptor controlled mechanisms. To investigate this possibility we performed a randomized, double-masked study involving 60 rabbit iatrogenic induced corneal ulcers produced with iodine vapour. Two beta specific drug compounds were tested, namely, betaxolol hydrochloride 0.25% (Alcon) (β1) and L132-468 (Sandoz, Basel) 0.25% (β2), and phosphate-buffered solution (PBS) as control. There was no statistical difference in the wound healing rates among all groups at 24 hours but there were significant differences at 48 hours (p<0.01). At 72 hours, the L132-468 treated groups showed significantly less healing than the betaxolol hydrochloride treated group. The PBS-treated group was healed at this time. By 20th post burning day, SEM revealed that betaxolol hydrochloride treated corneas were completely healed with normal epithelial microvilli. The L132-468 treated corneas were also healed but desquamation and abnormal cells were observed. In conclusion, beta-2 blockers inhibit corneal re-epithelialization more potently than beta-1 blockers. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：101 / 112

页数：12

共 10 条

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