POSSIBLE ROLE OF DIODOQUIN AS A ZINC IONOPHORE IN THE TREATMENT OF ACRODERMATITIS-ENTEROPATHICA

被引：24

作者：

AGGETT, PJ ^{[1
]}

DELVES, HT ^{[1
]}

HARRIES, JT ^{[1
]}

BANGHAM, AD ^{[1
]}

机构：

[1] INST ANIM PHYSIOL,CAMBRIDGE CB2 4AT,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91825-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism by which 5,7-di-iodo-8-hydroxy quinoline (Diodoquin) enhances zinc absorption in the zinc deficiency disorder acrodermatitis enteropathica was investigated using liposomes. This compound increased the permeability of the pure lipid membranes to 65Zn and it is proposed that the therapeutic effect of Diodoquin and related compounds may derive from their ability to act as ionophores. © 1979.

引用

页码：513 / 517

页数：5

共 12 条

[1]

Bangham A. D., 1974, METHODS MEMBRANE BIO, V1

[2] ACRODERMATITIS ENTEROPATHICA - RECENT FINDINGS CONCERNING CLINICAL FEATURES, PATHOGENESIS, DIAGNOSIS AND THERAPY [J].