Intestinal Permeability in Non-alcoholic Fatty LIVER Disease: The Gut-liver Axis

被引：28
|
作者：
Scarpellini, E. [1 ]
Lupo, M. [2 ]
Iegri, C. [2 ]
Gasbarrini, A. [3 ]
De Santis, A. [2 ]
Tack, J. [1 ]
机构：
[1] KULeuven, TARGID, Leuven, Belgium
[2] Sapienza Univ Rome, Umberto I Univ Hosp, Div Gastroenterol, Rome, Italy
[3] Gemelli Univ Hosp, Internal Med & Gastroenterol Div, Rome, Italy
来源：
REVIEWS ON RECENT CLINICAL TRIALS | 2014年 / 9卷 / 03期
关键词：
Intestinal permeability; zonulin-1; claudin; nafld; nash; lipopolysaccharide;
D O I：
10.2174/1574887109666141216104334
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The gut-liver axis model has helped to explain the liver steatosis (NAFLD) and steatohepatitis (NASH) etiopathogenesis. The discovery of a key role for an altered intestinal permeability (IP) in this pathophysioligcal framework has closed the link between gut lumen antigenic/toxic substances and systemic and liver inflammation in NAFLD and obesity, metabolic syndrome. Recent evidence from the literature show how IP can be modulated by several non-pharmacological and pharmacological agents and be the target for future preventive and curative treatment of NAFLD and NASH. In this review we describe the concept of IP, its ultrastructural basis, its role in the NALFD pathophysiology and emerging evidence on non-pharmacological and pharmacological agents able to favourably modulate it.
引用
收藏
页码：141 / 147
页数：7
相关论文
共 50 条
  • [1] Gut-liver axis, nutrition, and non-alcoholic fatty liver disease
    Kirpich, Irina A.
    Marsano, Luis S.
    McClain, Craig J.
    CLINICAL BIOCHEMISTRY, 2015, 48 (13-14) : 923 - 930
  • [2] Gut-Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease
    Poeta, Marco
    Pierri, Luca
    Vajro, Pietro
    CHILDREN-BASEL, 2017, 4 (08):
  • [3] Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease
    Paolella, Giulia
    Mandato, Claudia
    Pierri, Luca
    Poeta, Marco
    Di Stasi, Martina
    Vajro, Pietro
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (42) : 15518 - 15531
  • [4] Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease
    Giulia Paolella
    Claudia Mandato
    Luca Pierri
    Marco Poeta
    Martina Di Stasi
    Pietro Vajro
    World Journal of Gastroenterology, 2014, 20 (42) : 15518 - 15531
  • [5] Prebiotics targeting gut-liver axis to treat non-alcoholic fatty liver disease
    Castelnuovo, Gabriele
    Perez-Diaz-Del-Campo, Nuria
    Guariglia, Marta
    Poggiolini, Irene
    Armandi, Angelo
    Rosso, Chiara
    Caviglia, Gian P.
    Bugianesi, Elisabetta
    MINERVA GASTROENTEROLOGY, 2024, 70 (04): : 446 - 453
  • [6] ALKALINE CERAMIDASE 2 AS A MEDIATOR OF NON-ALCOHOLIC FATTY LIVER DISEASE THROUGH GUT-LIVER AXIS BY DECREASING INTESTINAL BARRIER PERMEABILITY
    Li, Fang
    Chen, Ye
    GASTROENTEROLOGY, 2020, 158 (06) : S1351 - S1351
  • [7] Deciphering the Gut-Liver Axis: A Comprehensive Scientific Review of Non-Alcoholic Fatty Liver Disease
    Singh, Samradhi
    Kriti, Mona
    Catanzaro, Roberto
    Marotta, Francesco
    Malvi, Mustafa
    Jain, Ajay
    Verma, Vinod
    Nagpal, Ravinder
    Tiwari, Rajnarayan
    Kumar, Manoj
    LIVERS, 2024, 4 (03): : 435 - 454
  • [8] New Insights into Nutrition and Gut-Liver Axis: A Focus on Non-Alcoholic Fatty Liver Disease
    Rodriguez-Ramiro, Ildefonso
    NUTRIENTS, 2023, 15 (23)
  • [9] Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease
    Compare, D.
    Coccoli, P.
    Rocco, A.
    Nardone, O. M.
    De Maria, S.
    Carteni, M.
    Nardone, G.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2012, 22 (06) : 471 - 476
  • [10] Gut-Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome
    Pezzino, Salvatore
    Sofia, Maria
    Faletra, Gloria
    Mazzone, Chiara
    Litrico, Giorgia
    La Greca, Gaetano
    Latteri, Saverio
    BIOLOGY-BASEL, 2022, 11 (11):
12345