CYTOTOXIC T-CELL SPECIFICITY FOR RESPIRATORY SYNCYTIAL VIRUS PROTEINS - FUSION PROTEIN IS AN IMPORTANT TARGET ANTIGEN

被引：103

作者：

PEMBERTON, RM ^{[1
]}

CANNON, MJ ^{[1
]}

OPENSHAW, PJM ^{[1
]}

BALL, LA ^{[1
]}

WERTZ, GW ^{[1
]}

ASKONAS, BA ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294

来源：

JOURNAL OF GENERAL VIROLOGY | 1987年 / 68卷

关键词：

D O I：

10.1099/0022-1317-68-8-2177

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We examined the specificity of BALB/c cytotoxic T (Tc) cells for respiratory syncytial virus (RSV) components, using recombinant vaccinia viruses (VV) coding for several individual RSV proteins. We found that immunization with the different VVs yielded the following Tc memory cell populations: high levels of RSV-specific Tc cells were induced with the fusion protein VV, but low levels were induced with VV coding for the RSV nucleoprotein. Tc cell recognition of attachment glycoprotein, part of the matrix molecule or 1A internal protein was poor. While high levels of fusion protein-specific Tc cells were induced by the fusion protein VV, they showed poor cross-reactivity between the A2 and 8/60 RSV strains compared with Tc cells primed by RSV infection.

引用

页码：2177 / 2182

页数：6

共 26 条

[1] EXPRESSION OF THE MAJOR GLYCOPROTEIN-G OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FROM RECOMBINANT VACCINIA VIRUS VECTORS [J].