PROGNOSTIC VALUE OF PLATELET-FUNCTION DISTURBANCES IN PATIENTS WITH UNSTABLE ANGINA (RESULTS OF ONE-YEAR FOLLOW-UP)

With the aim of a search for possible platelet related predictors of myocardial infarction development in unstable angina multifactorial discriminant analysis of relationship of platelet function characteristics to results of one year follow-up of 121 patients was performed. Nineteen parameters reflecting various platelet functions - aggregation in vivo and in vitro, lipid composition of and lipid penroxidation in platelets were included into analysis. The following 4 parameters had discriminating power in relation to myocardial infarction development (n=37) and sudden death (n=3) during follow-up: lipid peroxydation products (diene conjugates), tree cholesterol fraction and platelet phosholipids - phosphatidyl choline and sphingomyelin. Frequency of correct retrospective predictions when all these parameters were included into model was 70%, Best coincidence of predicted and observed results of follow up (76%) was achieved with the use of 3 parameters - free cholesterol, phosphatidyl choline and sphingomyelin in platelets.