IDENTIFICATION OF 2 HIGHLY HOMOLOGOUS PRESYNAPTIC PROTEINS DISTINCTLY LOCALIZED AT THE DENDRITIC AND SOMATIC SYNAPSES

被引：95

作者：

TAKAHASHI, S

YAMAMOTO, H

MATSUDA, Z

OGAWA, M

YAGYU, K

TANIGUCHI, T

MIYATA, T

KABA, H

HIGUCHI, T

OKUTANI, F

FUJIMOTO, S

机构：

[1] KOCHI MED SCH,DEPT IMMUNOL,NANKO KU,KOCHI 783,JAPAN

[2] NATL INST NEUROSCI,NCNP,DEPT IMMUNOL,KODAIRA,TOKYO 187,JAPAN

[3] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

[4] KOCHI MED SCH,MED RES LABS,NANKO KU,KOCHI 783,JAPAN

来源：

FEBS LETTERS | 1995年 / 368卷 / 03期

关键词：

PRESYNAPTIC PROTEIN; SYNAPSE; SOMA; DENDRITE; BRAIN (MOUSE);

D O I：

10.1016/0014-5793(95)00713-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity. Immunohistological study with the mAbs raised against the bacterially expressed 921 proteins showed that 921-L protein is distributed at the dendritic region and 921-S at the neuronal somatic surface. Immune-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses.

引用

页码：455 / 460

页数：6

共 23 条

[1] INHIBITORY SYNAPSES ON SOMAS OF PURKINJE CELLS IN CEREBELLUM [J].