Relationship between CA-125 and characteristics clinical and histopathological in epithelial ovarian cancer

Objective: To determine the clinical and histological features associated with CA-125 levels. Methods: The State Cancer Center records ISSEMyM 91 patients with diagnosis of epithelial ovarian cancer, of which CA-125 levels were obtained pretreatment, as well as the clinical and histological features of the tumor; values of CA-125 were log-normalized, analysis of variance, and t correlation test depending on the type of variable to be analyzed and inally a mult iple regression model was carried out, all of this was used to identify predictors was performed CA125 in the study population. Results: The presence of ascites, laterality, clinical stage, histological type and grade of differentiation show statistically signiicant associations with elevation of CA-125. We found that the number of pregnancies and the number of children was associated with increased CA-125 elevation, on the other hand, body mass index (BMI), tumor size and lymphovascular permeation showed no association with the elevation of this marker. The multiple regression model shows that the clinical stage, ascites, bilateral involvement, histologic type non-mucinous and poorly differentiated grade are the characteristics most CA-125 elevation. Conclusions: Clinical and histopathological, such as the presence of ascites, advanced clinical stage, bilaterality, differentiation grade and histological type are key features in the elevation of CA -125 determinants.