DELAYED ADMINISTRATION OF BASIC FIBROBLAST GROWTH-FACTOR PROTECTS AGAINST N-METHYL-D-ASPARTATE NEUROTOXICITY IN NEONATAL RATS

被引：31
作者：
NOZAKI, K
FINKLESTEIN, SP
BEAL, MF
机构：
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[2] MASSACHUSETTS GEN HOSP, CNS GROWTH FACTOR RES LAB, BOSTON, MA 02114 USA
[3] MASSACHUSETTS GEN HOSP, STROKE RES LAB, BOSTON, MA 02114 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 232卷 / 2-3期
关键词：
BFGF (BASIC FIBROBLAST GROWTH FACTOR); NMDA (N-METHYL-D-ASPARTATE); EXCITOTOXICITY (NEONATE); NEUROPROTECTION;
D O I：
10.1016/0014-2999(93)90788-J
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neuroprotective effects of basic fibroblast growth factor (bFGF) (200 mu/kg i.p.) were examined at different time points following intrastriatal injection of N-methyl-D-aspartate (NMDA) in seven-day-old rats. When administered 0.5 h before intrastriatal NMDA injection, 200 mug/kg of bFGF significantly reduced NMDA-induced lesion by 47% as compared with vehicle treatment. Posttreatment with the same dose of bFGF at 0, 0.5 or 1 h after NMDA injection also significantly reduced those lesions by 45, 35 or 26%, respectively, while no neuroprotective effects was observed when administered at 2 or 4 h after NMDA injection.
引用
收藏
页码：295 / 297
页数：3
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