Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

被引：0
作者：
Shapovalyants, O. S. [1 ]
Nikonova, T. V. [1 ]
机构：
[1] Endocrinol Res Ctr, Moscow, Russia
来源：
DIABETES MELLITUS | 2011年 / 14卷 / 02期
关键词：
type 1 mellitus diabetes; autoantibodies; immunnity; zinc transporter 8;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in the pancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigens which are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunity target.
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页码：18 / 22
页数：5
相关论文
共 43 条
  • [1] Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    Achenbach, P.
    Lampasona, V.
    Landherr, U.
    Koczwara, K.
    Krause, S.
    Grallert, H.
    Winkler, C.
    Pflueger, M.
    Illig, T.
    Bonifacio, E.
    Ziegler, A. G.
    [J]. DIABETOLOGIA, 2009, 52 (09) : 1881 - 1888
  • [2] Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient
    Arden, SD
    Roep, BO
    Neophytou, PI
    Usac, EF
    Duinkerken, G
    deVries, RRP
    Hutton, JC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) : 551 - 561
  • [3] IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE
    BAEKKESKOV, S
    AANSTOOT, HJ
    CHRISTGAU, S
    REETZ, A
    SOLIMENA, M
    CASCALHO, M
    FOLLI, F
    RICHTEROLESEN, H
    CAMILLI, PD
    [J]. NATURE, 1990, 347 (6289) : 151 - 156
  • [4] Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk
    Bingley, PJ
    Gale, EAM
    [J]. DIABETOLOGIA, 2006, 49 (05) : 881 - 890
  • [5] BONIFACIO E, 1995, J IMMUNOL, V155, P5419
  • [6] ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
    BOTTAZZO, GF
    FLORINCH.A
    DONIACH, D
    [J]. LANCET, 1974, 2 (7892) : 1279 - 1283
  • [7] IDENTIFICATION AND CLONING OF A GRANULE AUTOANTIGEN (CARBOXYPEPTIDASE-H) ASSOCIATED WITH TYPE-I DIABETES
    CASTANO, L
    RUSSO, E
    ZHOU, L
    LIPES, MA
    EISENBARTH, GS
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (06) : 1197 - 1201
  • [8] Endogenous ecotropic murine leukemia viral (MuLV) envelope protein as a new autoantigen reactive with non-obese diabetic mice sera
    Choi, SE
    Kim, KS
    Kim, KH
    Choi, UY
    Kim, HM
    Yoon, JW
    Kang, Y
    [J]. JOURNAL OF AUTOIMMUNITY, 2000, 15 (03) : 347 - 357
  • [9] INDUCTION AND THERAPY OF AUTOIMMUNE DIABETES IN THE NON-OBESE DIABETIC (NOD/LT) MOUSE BY A 65-KDA HEAT-SHOCK PROTEIN
    ELIAS, D
    MARKOVITS, D
    RESHEF, T
    VANDERZEE, R
    COHEN, IR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1576 - 1580
  • [10] GAMMA-AMINOBUTYRIC ACID OUTSIDE THE MAMMALIAN BRAIN
    ERDO, SL
    WOLFF, JR
    [J]. JOURNAL OF NEUROCHEMISTRY, 1990, 54 (02) : 363 - 372
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