Case Sharing in T-cell Lymphomas and Review of Angioimmunoblastic T-cell Lymphoma

Mature T-cell and natural killer-cell neoplasms can be classified into four categories based on site: cutaneous, extranodal, nodal, and leukaemic. Subtypes within these categories may be aggressive or indolent, with some indolent cases potentially undergoing aggressive transformation. However, both indolent and aggressive cases are potentially manageable with appropriate therapy. In this report, four patients, representing the four sites of disease, are described: cutaneous - mycosis fungoides; extranodal - natural killer/T-cell lymphoma nasal type; nodal - angioimmunoblastic T-cell lymphoma; and leukaemic - adult T-cell leukaemia/lymphoma. The published literature on potential therapeutic options for angioimmunoblastic T-cell lymphoma is reviewed.