INCREASED HYPOTHALAMIC NEUROPEPTIDE-Y MESSENGER-RNA LEVELS IN 2 RAT MODELS OF DIABETES

被引：22

作者：

JONES, PM ^{[1
]}

PIERSON, AM ^{[1
]}

WILLIAMS, G ^{[1
]}

GHATEI, MA ^{[1
]}

BLOOM, SR ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT MED,FRANCIS FRASER LAB,2ND FLOOR,DU CANE RD,LONDON W12 0NN,ENGLAND

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 01期

关键词：

NEUROPEPTIDE-Y; MESSENGER-RNA; HYPOTHALAMUS; DIABETES; RAT;

D O I：

10.1111/j.1464-5491.1992.tb01719.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated levels of immunoreactive hypothalamic neuropeptide Y have recently been reported both in streptozotocin-induced diabetic rats and in the spontaneously diabetic BB rat. We have measured the levels of neuropeptide Y encoding messenger ribonucleic acid (mRNA) in both of these rat models to determine whether an increase in neuropeptide Y gene expression is a contributory factor to the increases in hypothalamic neuropeptide Y immunoreactive peptide content. In the hypothalami of both the spontaneously diabetic BB/E and the streptozotocin-diabetic animals, neuropeptide Y mRNA showed significant elevations (to 204 +/- 13 % (+/- SE) and 387 +/- 48 % of control values, respectively, p < 0.01 for both). Our results demonstrate that two models of insulin-deficient diabetes in the rat are associated with increased hypothalamic neuropeptide Y mRNA. Taken with the known effects of neuropeptide Y on food intake these results suggest that increased neuropeptide Y synthesis in the hypothalamus may be related to the hyperphagia seen in the diabetic condition.

引用

页码：76 / 80

页数：5

共 23 条

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