DEPRESSED LEVELS OF CIRCULATING MENAQUINONES IN PATIENTS WITH OSTEOPOROTIC FRACTURES OF THE SPINE AND FEMORAL-NECK

被引：114

作者：

HODGES, SJ

PILKINGTON, MJ

STAMP, TCB

CATTERALL, A

SHEARER, MJ

BITENSKY, L

CHAYEN, J

机构：

[1] UNIV SURREY,ROBENS INST,CELLULAR PHARMACOL & TOXICOL UNIT,GUILDFORD GU2 5XH,SURREY,ENGLAND

[2] ROYAL NATL ORTHOPAED HOSP,LONDON W1N 6AD,ENGLAND

[3] GUYS HOSP,DEPT HAEMATOL,LONDON SE1 9RT,ENGLAND

[4] CHARING CROSS HOSP,LONDON W6 8RP,ENGLAND

来源：

BONE | 1991年 / 12卷 / 06期

关键词：

ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MENAQUINONES; OSTEOPOROSIS; VITAMIN-K;

D O I：

10.1016/8756-3282(91)90027-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin K1 functions in the conversion of glutamate residues, present in certain bone peptides, into the putatively active gamma-carboxyglutamate form. We have shown previously that the circulating levels of vitamin K1 are depressed in osteoporotic patients. However, it is known that menaquinones (vitamin K2:MK) may be more effective than vitamin K1 in this conversion of the inactive to active form of glutamate residues. A procedure for measuring such menaquinones has now demonstrated a marked deficiency of MK-7 and MK-8 in patients with osteoporotic fractures. It is suggested that estimates of circulating levels of K1, MK-7, and MK-8 might provide a biochemical risk marker of osteoporotic fractures.

引用

页码：387 / 389

页数：3

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