DEPRESSED LEVELS OF CIRCULATING MENAQUINONES IN PATIENTS WITH OSTEOPOROTIC FRACTURES OF THE SPINE AND FEMORAL-NECK

被引：114
|
作者：
HODGES, SJ
PILKINGTON, MJ
STAMP, TCB
CATTERALL, A
SHEARER, MJ
BITENSKY, L
CHAYEN, J
机构：
[1] UNIV SURREY,ROBENS INST,CELLULAR PHARMACOL & TOXICOL UNIT,GUILDFORD GU2 5XH,SURREY,ENGLAND
[2] ROYAL NATL ORTHOPAED HOSP,LONDON W1N 6AD,ENGLAND
[3] GUYS HOSP,DEPT HAEMATOL,LONDON SE1 9RT,ENGLAND
[4] CHARING CROSS HOSP,LONDON W6 8RP,ENGLAND
来源：
BONE | 1991年 / 12卷 / 06期
关键词：
ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MENAQUINONES; OSTEOPOROSIS; VITAMIN-K;
D O I：
10.1016/8756-3282(91)90027-G
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vitamin K1 functions in the conversion of glutamate residues, present in certain bone peptides, into the putatively active gamma-carboxyglutamate form. We have shown previously that the circulating levels of vitamin K1 are depressed in osteoporotic patients. However, it is known that menaquinones (vitamin K2:MK) may be more effective than vitamin K1 in this conversion of the inactive to active form of glutamate residues. A procedure for measuring such menaquinones has now demonstrated a marked deficiency of MK-7 and MK-8 in patients with osteoporotic fractures. It is suggested that estimates of circulating levels of K1, MK-7, and MK-8 might provide a biochemical risk marker of osteoporotic fractures.
引用
收藏
页码：387 / 389
页数：3
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