ISOLATION AND PARTIAL SEQUENCE OF A COLLAGEN GENE FROM THE HUMAN FILARIAL PARASITE BRUGIA-MALAYI

We report the isolation and sequence of a part of a gene encoding a collagen from the genome of the human filarial parasite Brugia malayi. The deduced amino acid sequence of the sequenced portion of this gene, which we have designated BmCo11, differs from the most catalogued nematode collagens in that it is composed predominantly of the glycine-X-Y motif, where either X or Y (or both) may be proline. The gene appears to be similar to two recently described Caenorhabditis elegans collagen genes whose deduced amino acid sequences resemble mammalian basement membrane collagens. BmCo11 is a single copy gene and appears to be present in several other parasitic nematodes examined.