ROLE OF PROTEIN-KINASE-C IN THE REGULATION OF GLUCAGON GENE-EXPRESSION BY ARGININE

被引：3
|
作者：
YAMATO, E [1 ]
IKEGAMI, H [1 ]
TAHARA, Y [1 ]
CHA, T [1 ]
YONEDA, H [1 ]
NOMA, Y [1 ]
SHIMA, K [1 ]
OGIHARA, T [1 ]
机构：
[1] UNIV TOKUSHIMA,SCH MED,DEPT LAB MED,TOKUSHIMA 770,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)91230-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cellular mechanism of glucagon gene expression in intact rat islets and their synthesis and release of glucagon were investigated. Arginine significantly increased the amounts of preproglucagon mRNA and glucagon in the islets and glucagon release. H-7, a specific inhibitor of protein kinase C (PKC), significantly inhibited these effects of arginine. However, H-8, a potent inhibitor of cyclic nucleotide-dependent protein kinases, did not affect the arginine-induced biosynthesis of glucagon or glucagon release. These results suggest that the regulation of glucagon gene expression by arginine is mediated by PKC, not by cyclic nucleotide-dependent protein kinases. © 1990.
引用
收藏
页码：898 / 904
页数：7
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