ROLE OF PROTEIN-KINASE-C IN THE REGULATION OF GLUCAGON GENE-EXPRESSION BY ARGININE

被引：3

作者：

YAMATO, E ^{[1
]}

IKEGAMI, H ^{[1
]}

TAHARA, Y ^{[1
]}

CHA, T ^{[1
]}

YONEDA, H ^{[1
]}

NOMA, Y ^{[1
]}

SHIMA, K ^{[1
]}

OGIHARA, T ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT LAB MED,TOKUSHIMA 770,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)91230-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular mechanism of glucagon gene expression in intact rat islets and their synthesis and release of glucagon were investigated. Arginine significantly increased the amounts of preproglucagon mRNA and glucagon in the islets and glucagon release. H-7, a specific inhibitor of protein kinase C (PKC), significantly inhibited these effects of arginine. However, H-8, a potent inhibitor of cyclic nucleotide-dependent protein kinases, did not affect the arginine-induced biosynthesis of glucagon or glucagon release. These results suggest that the regulation of glucagon gene expression by arginine is mediated by PKC, not by cyclic nucleotide-dependent protein kinases. © 1990.

引用

页码：898 / 904

页数：7

共 50 条

[21] THE PROTEIN-KINASE-C AND PROTEIN-KINASE-C RELATED GENE FAMILIES
DEKKER, LV
PALMER, RH
PARKER, PJ
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1995, 5 (03) : 396 - 402
[22] ROLE OF PROTEIN-KINASE-C ACTIVITY IN TUMOR-NECROSIS-FACTOR-ALPHA GENE-EXPRESSION - INVOLVEMENT AT THE TRANSCRIPTIONAL LEVEL
CHUNG, IY
KWON, JB
BENVENISTE, EN
JOURNAL OF IMMUNOLOGY, 1992, 149 (12): : 3894 - 3902
[23] THE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GUANOSINE TRIPHOSPHATE) GENE-EXPRESSION BY INSULIN IS NOT MEDIATED BY PROTEIN-KINASE-C
CHU, DTW
STUMPO, DJ
BLACKSHEAR, PJ
GRANNER, DK
MOLECULAR ENDOCRINOLOGY, 1987, 1 (01) : 53 - 59
[24] THE REGULATION AND FUNCTIONS OF PROTEIN-KINASE-C GENE-PRODUCTS
PARKER, PJ
BORNANCIN, F
CAZAUBON, S
DEKKER, L
KILEY, S
OLIVIER, AR
WHELAN, R
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 20 - 20
[25] THE REGULATION AND FUNCTIONS OF PROTEIN-KINASE-C GENE-PRODUCTS
PARKER, PJ
BORNANCIN, F
CAZAUBON, S
DEKKER, L
KILEY, S
OLIVIER, AR
WHELAN, R
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 66 - 66
[26] NEUROPEPTIDE PROTEIN-KINASE-C MEDIATED GENE-REGULATION
WEILL, CL
SQUINTO, SP
ZORN, NE
RUSSELL, DH
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 594 : 130 - 145
[27] ROLE OF PROTEIN-KINASE-C IN THE REGULATION OF GAP JUNCTIONAL COMMUNICATION
BUDUNOVA, IV
MITTELMAN, LA
MILOSZEWSKA, J
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 1994, 14 (06): : 259 - 270
[28] ROLE FOR PROTEIN-KINASE-C IN THE CONSTITUTIVE EXPRESSION OF PTH-RELATED PEPTIDE GENE
INOUE, D
MATSUMOTO, T
IKEDA, K
JOURNAL OF BONE AND MINERAL RESEARCH, 1993, 8 : S202 - S202
[29] ROLE OF MEMBRANE DEFECTS IN THE REGULATION OF THE ACTIVITY OF PROTEIN-KINASE-C
SENISTERRA, G
EPAND, RM
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (01) : 378 - 383
[30] REGULATION AND THE ROLE OF PROTEIN-KINASE-C IN HUMAN NEUTROPHIL ACTIVATION
BOXER, LA
BALAZOVICH, KJ
CURNUTTE, JT
SMOLEN, JE
FEDERATION PROCEEDINGS, 1986, 45 (04) : 1136 - 1136

← 1 2 3 4 5 →