CHROMATOGRAPHIC ANALYSIS OF CHLORPHENIRAMINE, PYRILAMINE, AND METHAPYRILENE IN COMBINATION

被引：8
作者：
RADER, BR
机构：
[1] Food and Drug Administration, Department of Health, Education, and Welfure, Los Angeles, California
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 12期
关键词：
Chlorpheniramine; pyrilamine; methapyrilene combination—analysis; Column chromatography—separation; GLC—analysis; UV spectrophotometry—analysis;
D O I：
10.1002/jps.2600581226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A partition chromatographic method is presented for the separation and quantitation of chlorpheniramine, methapyrilene, and pyrilamine in combination. A solution of p‐toluenesulfonic acid and potassium chloride on a column of diatomaceous earth is used to effect the separation. The isolated chlorpheniramine is determined by UV spectrophotometry. The methapyrilene and pyrilamine are separated and determined by GLC. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
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页码：1535 / &
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