Circulating microRNAs in patients with non-alcoholic fatty liver disease

被引：71

作者：

Celikbilek, Mehmet ^{[1
]}

Baskol, Mevlut ^{[1
]}

Taheri, Serpil ^{[2
]}

Deniz, Kemal ^{[3
]}

Dogan, Serkan ^{[1
]}

Zararsiz, Gokmen ^{[4
]}

Gursoy, Sebnem ^{[1
]}

Guven, Kadri ^{[1
]}

Ozbakir, Omer ^{[1
]}

Dundar, Munis ^{[2
]}

Yucesoy, Mehmet ^{[1
]}

机构：

[1] Erciyes Univ, Dept Gastroenterol, Med Sch, TR-38039 Kayseri, Turkey

[2] Erciyes Univ, Dept Med Genet, Med Sch, TR-38039 Kayseri, Turkey

[3] Erciyes Univ, Dept Pathol, Med Sch, TR-38039 Kayseri, Turkey

[4] Erciyes Univ, Dept Biostat & Med Informat, Med Sch, TR-38039 Kayseri, Turkey

来源：

WORLD JOURNAL OF HEPATOLOGY | 2014年 / 6卷 / 08期

关键词：

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; MicroRNA; Noninvasive; Serum markers;

D O I：

10.4254/wjh.v6.i8.613

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a and miR-29a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR99a were inversely correlated with serum gamma glutamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered serum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：613 / 620

页数：8

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