Role of the Gut Microbiota in Ischemic Stroke

被引：0
作者：
Winek, Katarzyna [1 ,2 ,3 ]
Dirnagl, Ulrich [1 ,2 ,3 ,5 ,6 ]
Meisel, Andreas [1 ,2 ,3 ,4 ]
机构：
[1] Charite Univ Med Berlin, Expt Neurol, Charitepl 1, D-10117 Berlin, Germany
[2] Charite Univ Med Berlin, NeuroCure Clin Res, Berlin, Germany
[3] Charite Univ Med Berlin, Ctr Schlaganfallforsch Berlin, Berlin, Germany
[4] Charite Univ Med Berlin, Neurol Klin, Berlin, Germany
[5] Standort Berlin, Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Berlin, Germany
[6] Standort Berlin, Deutsch Zentrum Herz Kreislauf Forsch DZHK, Berlin, Germany
来源：
AKTUELLE NEUROLOGIE | 2018年 / 45卷 / 02期
关键词：
microbiota; microbiome; stroke; CNS;
D O I：
10.1055/s-0043-108060
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent studies have provided evidence for the role of the gut microbiota in homeostasis of the central nervous system (CNS) and pathophysiology of its disorders, e.g. by regulation of the peripheral immune response. In this manuscript, we discuss the importance of the gut microbiota in stroke, by providing a summary of available clinical and experimental data suggesting that 1) stroke changes the gut microbiome, 2) microbiota modulate stroke outcome and 3) microbiota play an important role in the pathogenesis of stroke (risk factors). Currently available clinical and experimental evidence suggests an important role of gut microbiota in stroke and promises clinically relevant discoveries within the next years.
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收藏
页码：127 / 134
页数：8
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